But when the moment arrived, “McSteamy” was missing from the stage as the effects of his “nasty disease” sidelined him and landed him in hospital.

For years, Eric Dane captivated audiences as Dr. Mark Sloan – the irresistibly charming “McSteamy” – on Grey’s Anatomy, later earning critical acclaim for his role in HBO’s Euphoria.

But in April 2025, the 52-year-old actor revealed he had been diagnosed with amyotrophic lateral sclerosis (ALS), the progressive and incurable neurological disease more commonly known as Lou Gehrig’s.

“I have been diagnosed with ALS,” he told People at the time, expressing gratitude for his wife Rebecca Gayheart and their daughters, Billie and Georgia. “I am grateful to have my loving family by my side as we navigate this next…I kindly ask that you give my family and I privacy during this time.”

ALS
Over time, ALS robs patients of the ability to walk, speak, and even breathe independently.

According to the Mayo Clinic, ALS is a “nervous system disease that affects nerve cells in the brain and spinal cord. ALS causes loss of muscle control. The disease gets worse over time…There is no cure for this fatal disease.”

While survival time varies, the disease has claimed the lives of Lou Gehrig – the legendary baseball player who died in 1941 – SpongeBob SquarePants creator Stephen Hillenburg, and Bryan Randall, partner of actress Sandra Bullock.

One of the most famous people to live with the disease was physicist Stephen Hawking, who survived for decades before passing away in 2018.

Mobility loss
Only one month after he announced he had ALS, Dane spoke with Diane Sawyer on Good Morning America, candidly describing how quickly the progressive degenerative disease was taking away mobility in his arms.

“I didn’t really think anything of it at the time. I thought maybe I’d been texting too much, or my hand was fatigued, but a few weeks later I noticed it got a little worse,” he explained. “My dominant side. My left side is functioning; my right side has completely stopped working. It’s going. I feel like maybe a couple, few more months, and I won’t have my left hand either. It’s sobering.

“I will never forget those three letters,” Dane said. “It’s on me the second I wake up. It’s not a dream…I don’t think this is the end of my story. I don’t feel like this is the end of me.”

‘Ride this ‘till the wheels fall off’
Also in June, he spoke with E! News and expressed his willpower to keep moving forward with doing everything he loves, despite the quick progression.

“I’m going to ride this ‘till the wheels fall off,” the actor said. “It keeps me sharp. It keeps me moving forward, which is super important right now.

“I feel great when I’m at work. Of course, there have been some sort of setbacks, but I feel pretty good. My spirit is always pretty buoyant, so at the end of the day, that’s all that matters.”

‘Nasty disease’
But the emotional toll of ALS became painfully clear when ALS prevented him doing something he was “really looking forward to.”

Dane had been scheduled to present at the 2025 Emmy Awards in mid-September alongside his former Grey’s Anatomy co-star Jesse Williams, as part of a special tribute marking the show’s 20th anniversary – but he was forced to miss the ceremony.

In a recent interview with Washington Post, Dane revealed that shortly before the Emmys, he lost his balance – a debilitating effect of ALS – and fell hard in his kitchen.

“ALS is a nasty disease…So I was in the hospital during the Emmys getting stitches put in my head,” Dane told the Post. “I missed an opportunity I was really looking forward to. It would have been great to see Jesse and get reunited with some of my peers, and to be able to present in front of my colleagues I thought would have been a special moment.

“So, I was really upset about it, but you know, there was nothing I could do about it.”

‘Gonna go out helping somebody’
Despite his decline, Dane continues advocating for more research and support for neurodegenerative diseases. He hopes his experience can offer comfort to others and wants the attention on his battle to serve a greater purpose.

“This is something I felt compelled to share with people,” Dane told the Post. “This is more of a: ‘How can I help? How can I be of some service?’”

He added, “Not to be overly morbid, but you know, if I’m going out, I’m gonna go out helping somebody.”

For fans who adored him as McSteamy, Dane’s resilience in the face of a “nasty disease” is both heartbreaking and inspiring – a reminder of how fragile life can be, even for the brightest stars.